SILKOELASTOGRAFT aims at developing a sustainable strategy for the production of vascular graft with a compliance calibrated on the characteristics of the implant site and/or on the patient profile, so to reduce adverse event occurrence such as the thrombogenesis or intima hyperplasia.
It is an innovative approach to vascular access, hybrid, semi-degradable and suited for native tissue regeneration. Bioengineering Laboratories’ compliance-calibrated Silkothane® graft will integrate the biocompatibility and remodeling capability of silk fibroin with the elasticity and stability of polyurethanes, thus joining the short-term advantages of synthetic grafts (suitability for early cannulation) with the long term performances of native fistulae (remodeling and puncture regeneration). The graft will answer the industrial needs of acceptable manufacturing costs, reasonable lead time, reproducibility and compliance with regulatory and certification requirements in terms of safety and quality controls, without renouncing to patient-specificity